Imaging real-time single-molecule dynamics in genome regulation - Beat Fierz - NGBS2024

Imaging real-time single-molecule dynamics in genome regulation Speaker: Beat Fierz, Ecole Polytechnique Fédérale de Lausanne, Switzerland Chair: David Rueda, Imperial College, London/MRC-LMS, UK Co-Chair: Christopher Batters, MRC Laboratory of Molecular Biology, UK Beat Fierz describes this work to understand the molecular details of how chromatin organisation effects gene regulation. He focuses on the modification of histones by set of enzymes (the ubiquitin ligase PRC1; the PRC methyltransferase; and a deubiquitinase) involved in polycomb gene silencing. Using single-molecule techniques, he examines the effects of ubiquitination on the organization of chromatin using FRET and details the kinetics of binding and the ubiquitation ligation reaction by PRC1 by TIRF. Read more about Beat Fierz’s work here: https://www.epfl.ch/labs/lcbm/fierz/ You can find more about the Next Generation Biophysics Symposium 2024 here: https://www3.mrc-lmb.cam.ac.uk/sites/nextgen/ -- About the MRC Laboratory of Molecular Biology (LMB): The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Our scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health. More links: Official Site: https://www2.mrc-lmb.cam.ac.uk/ Facebook: https://www.facebook.com/MRC.LMB X/Twitter: https://twitter.com/MRC_LMB Instagram: https://www.instagram.com/mrc_lmb/ LinkedIn: https://www.linkedin.com/company/mrc-laboratory-of-molecular-biology Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: https://www.youtube.com/user/LMBCambridge?sub_confirmation=1