7. Glucose Titration Curve | Renal Physiology Made Easy | USMLE Step 1

𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩‍⚕‍ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊 📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺 : https://www.instagram.com/clinical.learning/ Glucose Titration Curve | Renal Physiology Made Easy | USMLE Step 1 The glucose titration curve describes the renal handling of glucose — including filtration, reabsorption, and eventual excretion — and illustrates key transport thresholds in proximal tubule physiology. Normally, glucose is freely filtered at the glomerulus and completely reabsorbed in the proximal convoluted tubule via SGLT2 (sodium-glucose cotransporter) up to a plasma glucose concentration of ~200 mg/dL. Beyond this, glucosuria begins to appear — this point is known as the threshold 🧪. However, due to nephron heterogeneity, some glucose appears in urine even before the reabsorptive maximum is reached. The transport maximum (Tm) is around 375 mg/min, beyond which all transporters are saturated and excess glucose is excreted in urine. The curve exhibits a nonlinear, sigmoidal shape — initially linear (as reabsorption matches filtration), then plateaus when Tm is reached, showing saturation kinetics. This is clinically relevant in conditions like diabetes mellitus, SGLT2 inhibitor use, and Fanconi syndrome. Understanding the glucose titration curve is key in renal physiology, pharmacology, and pathology for Step 1 and other board exams 🔬🧠. #GlucoseTitrationCurve #RenalPhysiology #USMLEStep1 #NEETPG #FMGEprep #DrSreeTeja #SGLT2 #Glucosuria #DiabetesPhysiology #ProximalTubule #TmThreshold #MBBSnotes #BoardExamPrep #MedicalEducation #PhysiologyShorts