5. GFR Regulation Simplified | Renal Physiology for USMLE Step 1 | Dr. Sree Teja

𝐒𝐮𝐛𝐬𝐜𝐫𝐢𝐛𝐞 𝗙𝐨𝐫 𝗠𝐨𝐫𝐞 𝗜𝐧𝐟𝐨𝐫𝐦𝐚𝐭𝐢𝐨𝐧 𝐨𝐧 𝗛𝐞𝐚𝐥𝐭𝐡 👩‍⚕‍ 𝐚𝐧𝐝 𝗠𝐞𝐝𝐢𝐜𝐢𝐧𝐞💉🩺💊 📌𝗜𝗻𝘀𝘁𝗮𝗴𝗿𝗮𝗺 : https://www.instagram.com/clinical.learning/ GFR Regulation Simplified | Renal Physiology for USMLE Step 1 | Dr. Sree Teja Glomerular Filtration Rate (GFR) represents the volume of plasma filtered across the glomerular capillaries into Bowman’s space per unit time — and is tightly regulated to maintain renal and systemic homeostasis 🧠💧. GFR is directly proportional to glomerular capillary hydrostatic pressure and inversely proportional to both Bowman’s space hydrostatic pressure and plasma oncotic pressure. Key regulators include afferent and efferent arteriolar tone: afferent arteriolar dilation (e.g., via prostaglandins) ↑ GFR, while afferent constriction (e.g., due to NSAIDs) ↓ GFR. Efferent arteriolar constriction (mediated by angiotensin II) helps maintain or increase GFR under low perfusion states, whereas ACE inhibitors, by dilating the efferent arteriole, reduce GFR. Conditions like hypovolemia, renal artery stenosis, or sympathetic overactivity lead to decreased renal perfusion and GFR. Increased Bowman’s capsule pressure (e.g., from obstruction) also reduces GFR. In contrast, decreased plasma proteins lower oncotic pressure, transiently increasing GFR. These principles are critical for USMLE Step 1 in interpreting renal autoregulation, pharmacology (NSAIDs, ACE inhibitors), and pathology (e.g., nephrotic syndrome, hypovolemia) 🩺📚. #USMLEStep1 #RenalPhysiology #GFRRegulation #DrSreeTeja #KidneyFunction #Nephron #HighYieldPhysiology #InternalMedicineUSMLE #Step1Concepts #MedicalEducation #USMLEShorts #BoardExamPrep #GlomerularFiltration #MCQRevision #DoctorYouTube