NACK S15.1: Introduction to Microfluidics

2021.11.05 Terry Kuzma, Pennsylvania State University This presentation is part of the NACK - Nano-Educators Topical Seminar Series and can be found at: https://nanohub.org/resources/35662 Information on the NACK Network can be found at: https://www.cneu.psu.edu/ and https://nano4me.org Prof. Terence Kuzma will discuss how modern manufacturing processes are used to create lab on a chip devices. He will discuss the unique physics of fluids on the microscale, and the solutions to meet these challenges. A hands on experience from a teaching cleanroom on the fabrication of the microfluidic channels will be discussed while sharing the detailed recipes. Simulation of a microfluidic channel to separate red blood cells will also be covered as an immediate application. Table of Contents: 00:00 Introduction to Microfluidics 04:50 Outline 08:02 What is Microfluidics 11:58 What is Microfluidics 15:10 Micro Arrays 18:23 Micro Arrays 18:27 Advantages/Disadvantes 21:39 Growth of Microarrays 22:05 Growth of Microarrays 25:27 Outline 25:35 Physics of Microfluidics 28:23 Electro-osmosis 29:03 Electro-Osmonic Flow (EOF) 29:20 Some Non-ideal Considerations 33:06 Laminar Flowis the Norm 34:51 Laminar Flow 35:51 Reynolds Number (estimating mixing) 36:56 Reynolds Number 37:40 Reynolds Number Effects 38:12 Reynolds Number 38:59 Laminar flow depends upon boundary geometry 40:25 Water in a 50 um channel 41:24 Peciet Number (diffusion) 42:49 Mixers (simple design to mix) 43:57 Mixers 44:50 Common Materials 49:35 Common Materials 51:43 Common Materials 52:39 Common Materials 53:39 Common Materials 55:43 Common Materials (cheap stuff) 57:41 Dimensions of a gene chip 58:54 Conclusion This presentation and related downloads can be found on nanoHUB.org at: https://nanohub.org/resources/36351