Sometimes a flatter, more natural full frequency overdrive sound can work best and other times an overdrive pedal with a pronounced mid hump can be a better choice. Here's some of the main things I consider to help me choose between the two.
Which type do you find works best for you and your setup?
00:00 - Intro
00:43 - Single Coil Pickups
02:04 - Humbucker Pickups
03:25 - With a Clean Amp
04:55 - With a Lightly Driven Amp
06:35 - Different Amps and Speakers
07:34 - How It Sounds in the Mix
08:54 - What About Everything In Between?