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Rates of colorectal cancer have declined in people over 65 but doubled among people under 50 in the last few decades. By 2030 it’s expected to be the leading cancer-related death in this age group.
In today’s episode, gastrointestinal cancer and prevention specialist, Dr. Andy Chan, explains how changes in the gut microbiome could be to blame.
Dr. Chan discusses the critical role your diet plays in cancer risk, how your gut microbiome can influence the development of colon cancer and the steps you can take to lower your risk.
Dr. Andy Chan is a Professor of Medicine at Harvard Medical School and Program Director for Gastroenterology training at Massachusetts General Hospital.
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Timecodes
00:00 Introduction
04:54 What is colon cancer?
06:17 How does cancer develop?
09:44 How common is colon cancer?
11:55 Demographics and shifting trends
14:48 Leading cause of cancer death for men under 50
16:28 Why are cancer rates rising in younger people
18:06 The role of diet and obesity
20:30 Does alcohol have an impact?
22:07 What is metabolic health and why does it matter?
26:05 Gut health and colon cancer
27:22 Evidence from animal studies
36:11 Why overuse of antibiotics can be harmful
40:40 Screening recommendations and methods
47:08 Can changing your diet reduce risk?
52:17 Should we avoid red meat?
55:00 Does physical activity reduce risk?
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Fibre Fuelled by Dr Will Bulsiewicz https://amzn.to/4bzmUXP
Mentioned in today’s episode:
Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer, from Gastroenterology https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957737/
Reducing Risk for Colorectal Cancer, from Center for Disease Control & Prevention https://www.cdc.gov/colorectal-cancer/prevention/?CDC_AAref_Val=https://www.cdc.gov/cancer/colorectal/basic_info/prevention.htm
Colorectal cancer statistics, 2017, from CA Cancer Journal https://pubmed.ncbi.nlm.nih.gov/28248415/
Association Between the Sulfur Microbial Diet and Risk of Colorectal Cancer, from Gastroenterology and Hepatology
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2786028
Fusobacterium nucleatum and colorectal cancer: From phenomenon to mechanism, from Frontiers in Cellular and Infection Microbiology https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9745098/
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Episode transcripts are available here: https://zoe.com/learn/category/podcasts