Dr. Steve Horvath on epigenetic aging to predict healthspan: the DNA PhenoAge and GrimAge clocks

Steve Horvath, PhD, ScD is a professor of human genetics and biostatistics at UCLA's Fielding School of Public Health. Dr. Horvath is the creator of the Horvath Epigenetic Aging Clock. His work incorporates elements of biostatistics, genetics, epidemiology, epigenomics, and other fields of study. He applies his understanding of this diverse range of disciplines to study a spectrum of chronic diseases, including cancer, cardiovascular disease, neurodegenerative disease, and other diseases of aging. Dr. Horvath's so-called "pan-tissue epigenetic aging clock" is an algorithm that accurately predicts a person's chronological age from marks on the DNA across multiple cells, tissues, and organs, and even mammalian species. Further refining this initial algorithm, Dr. Horvath built on this to develop second-generation clock algorithm that could predict time-to-death among people of the same chronological age, as well as lifespan and healthspan. One of these clocks, the GrimAge clock, is named deliberately after its connotation: predicting time until death ("Grim"). In this episode, Dr. Steven Horvath describes epigenetic clocks and their role in predicting – and possibly slowing – aging EPISODE LINKS: Show notes and transcript: https://www.foundmyfitness.com/episodes/steve-horvath?utm_source=youtube&utm_medium=youtube&utm_campaign=horvath_interview Dr. Steve Horvath's faculty bio page: https://ph.ucla.edu/faculty/horvath Dr. Steve Horvath's Wikipedia page: https://en.wikipedia.org/wiki/Steve_Horvath PODCAST INFO: Email: https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=horvath_interview Apple Podcasts: https://podcasts.apple.com/us/podcast/062-dr-steve-horvath-on-epigenetic-aging-to-predict/id818198322?i=1000503234644 Spotify: https://open.spotify.com/episode/0jMd5uqKjzCyFU3CpDMxix Full interview playlist: https://www.youtube.com/playlist?list=PLJEEAVzHu9KzgkQbe2Thh35VU-HCiId_s Clips playlist: https://www.youtube.com/playlist?list=PLrGxo-5Uw8gI9-1IStYEvNxVukKxZBlmi Dr. Rhonda Patrick's 3-minute video crash course in epigenetics: https://www.foundmyfitness.com/episodes/epigenetic-clock?utm_source=youtube&utm_medium=youtube&utm_campaign=horvath_interview The FoundMyFitness OVERVIEW ARTICLE on epigenetic clocks: https://www.foundmyfitness.com/topics/epigenetic-clocks?utm_source=youtube&utm_medium=youtube&utm_campaign=horvath_interview CHAPTERS 00:00:00 - Introductions 00:00:34 - Horvath Aging Clock 00:01:50 - Explaining the error rate 00:06:42 - Hereditary + lifestyle factors 00:15:03 - DNAm PhenoAge vs GrimAge 00:22:50 - Telomere science shortcomings 00:26:08 - Prolonging the epigenetic clock 00:50:56 - Epigenetics: Cause or consequence of aging? 00:56:53 - Vitamin D reverses epigenetic age 00:59:20 - Omega-3 slows down the GrimAge clock 01:04:27 - Ongoing research SCIENCE OF HEALTHSPAN EMAIL NEWSLETTER: Receive emailed episode notifications and regular updates on the emerging science of healthspan. https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=horvath_interview SUPPORT THE CHANNEL: Many of the magnificent resources associated with the FoundMyFitness channel exist directly as a result of our premium membership. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of all of the otherwise free resources provided by FoundMyFitness at https://www.foundmyfitness.com/crowdsponsor?utm_source=youtube&utm_medium=youtube&utm_campaign=horvath_interview Thank you for watching! SOCIALS: https://twitter.com/foundmyfitness https://facebook.com/foundmyfitness https://instagram.com/foundmyfitness PODCAST: Apple Podcasts: https://podcasts.apple.com/us/podcast/foundmyfitness/id818198322 Spotify: https://open.spotify.com/show/5QjpaU0o1Q2MkVZwwG3y7d ⏳ #aging #longevity #epigenetics 🧬