DHEA and Pregnenolone are powerful hormones.
In this Lecture by Dave Lee he discusses: dhea for men, pregnenolone for men, dhea benefits, pregnenolone benefits, dhea dosage, pregnenolone dosage, dhea and pregnenolone on TRT (testosterone replacement therapy), and much more!
➜➜ WATCH Part 2 (Follow-Up) of this Lecture here:
https://youtu.be/U1WrcF3RHaM
00:00 intro
02:35 Understand the function and importance of hormones in the brain.
06:56 Pregnenolone serves as a reservoir for the body.
09:09 Pregnenolone sulfate acts as a negative allosteric modulator of GABA receptor.
13:40 Pregnenolone benefits brain health and function.
16:04 DHEA metabolizes into various hormones with implications on HRT.
20:13 DHEA and DHEAs work together to protect and support the brain.
22:26 DHEA at high doses improved depression symptoms
26:57 Supplementing with pregnenolone and DHEA may support hormone levels.
29:06 Pregnenolone effects vary, can induce sleep or wakefulness depending on individual biochemistry.
33:17 DHEA and pregnenolone effects depend on sulfated forms and enzyme production.
35:41 Micronized sustained release oral form bypasses liver metabolism for slow absorption
39:48 DHEA recommendations range from 1 to 100 milligrams, but dosages vary based on individual needs and quality of supplements.
42:01 Cortisol is essential for survival
46:32 DHEA is preferentially converted into estrogen and estradiol when on TRT, so optimal dosing is crucial.
48:46 Ensure optimal cholesterol levels for hormone balance
53:22 Regular blood work is crucial for monitoring Pregnenolone and DHEA levels over time.
55:29 Optimizing hormone levels is key for individual well-being.
59:46 Optimizing DHEA and pregnenolone levels is crucial for older individuals
1:01:58 Gradually increase hormonal supplements for better results
1:05:54 Hormone balance is crucial for feeling good.
1:08:02 Work with a doctor for hormone management to avoid negative effects.
#trtandhormoneoptimization #trt #hormoneoptimization
Recommended DHEA: https://amzn.to/3lyC3Pu
Recommended Pregnenolone: https://amzn.to/31K9WF7
Links provided by Dave Lee:
https://www.sciencedirect.com/science/article/abs/pii/S0960076015300893?via%3Dihub
Kliewer SA, Lehmann JM, Milburn MV, Willson TM (1999). "The PPARs and PXRs: nuclear xenobiotic
receptors that define novel hormone signaling pathways". Recent Prog. Horm. Res. 54: 345–67, discussion
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