Cryo-EM14 lecture 2: Image formation, fourier analysis and CTF theory - Sjors Scheres

Sjors Scheres' group is interested in developing methods that allow visualisation of macromolecular machines in their multitude of natural states in order to understand how they work, as well as using these methods to determine the structures of unfolded amyloid proteins that are extracted from the brains of individuals with neurodegenerative diseases, like Alzheimer's and Pick's disease. Sjors is the main developer of RELION, a popular software package for cryo-EM structure determination. Read more about Sjors' work here: https://www2.mrc-lmb.cam.ac.uk/group-leaders/n-to-s/sjors-scheres/ Read more about RELION here: https://www2.mrc-lmb.cam.ac.uk/relion You can find more videos from the 2014 LMB Cryo-EM course here: https://www.youtube.com/playlist?list=PLQbPquAyEw4c5NHlu98DKPfwdbT-H7l6e Other playlists you might be interested in: Electron Cryo-Microscopy Course 2017 - https://www.youtube.com/playlist?list=PLQbPquAyEw4etKtxyqcvZz4uELPeLDLeF Electron Cryo-Microscopy - https://www.youtube.com/playlist?list=PLQbPquAyEw4eA1A7vNIxd7AzXzPHyW2Sp RELION - https://www.youtube.com/playlist?list=PLQbPquAyEw4fofIO5ik8d-AwRRp-L4Db9 Research Highlights from our Structural Studies Division - https://www.youtube.com/playlist?list=PLQbPquAyEw4edDbQPPhYtkhUPZ_QBx9vD -- About the MRC Laboratory of Molecular Biology (LMB): The LMB is one of the world's leading research institutes. Discoveries and inventions developed at the LMB, for example DNA sequencing and methods to determine the structure of proteins, have revolutionised all areas of biology. Its scientists work to advance understanding of biological processes at the molecular level. This information will help us to understand the workings of complex systems, such as the immune system and the brain, and solve key problems in human health. More links: Official Site: https://www2.mrc-lmb.cam.ac.uk/ Facebook: https://www.facebook.com/MRC.LMB Twitter: https://twitter.com/MRC_LMB Instagram: https://www.instagram.com/lmbnews/ LinkedIn: https://www.linkedin.com/company/mrc-laboratory-of-molecular-biology Click here to subscribe to MRC Laboratory of Molecular Biology on YouTube: https://www.youtube.com/user/LMBCambridge?sub_confirmation=1