Breakthroughs in Cancer: Carolyn Bertozzi, PhD | Stanford Cancer Institute

"Targeting the Glycocalyx for Cancer Immune Therapy," presented by Nobel Laureate and BIC inaugural speaker Carolyn Bertozzi, PhD. Bertozzi is Professor of Chemistry and Professor of Chemical & Systems Biology at Stanford University. In late 2022, Bertozzi was awarded the Nobel Prize in chemistry for her development of bioorthogonal reactions, which allow scientists to explore cells and track biological processes without disrupting the normal chemistry of the cell. #oncology #cancerresearch #immunotherapy Learn more about our Breakthroughs in Cancer seminar series: https://med.stanford.edu/cancer/training/events/breakthroughs.html Learn more about the Stanford Cancer Institute: https://med.stanford.edu/cancer Follow the Stanford Cancer Institute LinkedIn: https://www.linkedin.com/company/stanford-cancer/ Twitter: https://twitter.com/StanfordCancer Subscribe to the Stanford Cancer Institute: https://www.youtube.com/@stanfordcancerinstitute/ Key Chapters: Introductory remarks by SCI Director Steven Artandi, MD, PhD: 00:00 Remarks from David Entwistle, CEO of Stanford Health Care: 1:55 Carolyn Bertozzi, PhD, takes the podium: 4:25 Tribute to Prof. Chris T. Walsh: 4:40 Presentation begins: 7:03 Activating and Inhibitory cell receptors: 11:35 Clinical Data of Checkpoint Inhibitors: 14:56 Sialic Acid-Binding lg-like lectins (Siglecs): 20:45 Development of Therapeutic Strategies: 28:37 Antibody-Sialidase Conjugates: 31:53 Clinical Translations at Palleon Pharmaceuticals: 40:56 Clinical Trial for E-602 Phase 1/2 at Stanford: 43:13 MYC Over Expression: 45:30 Presentation Summary: 54:27 Thank You and Acknowledgements: 55:30 Q&A Session: 56:48