102: How Lectins Disrupt Insulin, Gut Health, and Immunity with Dr. Ben Bikman

📢 Dr. Bikman’s Coaching Site, Insulin IQ: https://insuliniq.com 📢 Become an Insider on Ben’s website: https://www.benbikman.com In this lecture, Dr. Bikman introduces lectins as harmful plant-derived proteins often found in carbohydrate-rich foods like legumes, grains, and nightshades. While these molecules serve as plant defense mechanisms, in humans they can bind to gut lining cells, disrupting tight junctions and increasing gut permeability (leaky gut). This disruption allows bacterial fragments (e.g., LPS) to enter circulation, triggering systemic inflammation, which in turn increases insulin resistance, autoimmune reactivity, and cardiometabolic risk. Lectins are also molecular mimics, capable of binding to insulin receptors and partially triggering insulin-like effects. This can lead to inappropriate fat storage, lipogenesis, and eventually insulin resistance as receptors become desensitized. Some lectins, like wheat germ agglutinin (WGA), have been shown in studies to both mimic and interfere with insulin signaling in fat cells—promoting fat gain and metabolic dysfunction even independent of calories. Lectins are linked to obesity, cardiovascular disease, fatty liver, and autoimmune disorders. They can increase inflammatory cytokines, damage liver mitochondria, promote oxidative stress, and worsen non-alcoholic fatty liver disease (NAFLD). In susceptible individuals, lectins can also drive autoimmune flares, with evidence pointing to their role in molecular mimicry, leading to the generation of autoantibodies and aggravated immune responses. While cooking methods like pressure cooking or fermenting can reduce lectin levels by up to 95%, they are never fully eliminated. Dr. Bikman concludes that for individuals with autoimmunity, insulin resistance, gut issues, or cardiovascular risk, reducing lectin intake may be wise. Monitoring markers like CRP, fasting insulin, and blood glucose can offer clues to lectin sensitivity, and while more human studies are needed, the biological plausibility and clinical observations make a strong case for dietary caution. Show Notes/References: For complete show notes and references, we invite you to become an Insider subscriber. You’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A after the lecture with Ben, ad-free podcast episodes, show notes and references, online Office Hours access, Ben’s Research Reviews Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more: https://www.benbikman.com Translation Notes: You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into Polish, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose Polish.) In addition, our channel has first access to YouTube’s new, innovative “auto-dubbing” feature. The process currently supports translations from English into French, German, Hindi, Indonesian, Italian, Japanese, Portuguese, and Spanish. Click on the gear icon, then choose “Audio track” to access. #Lectins #LeakyGut #InsulinResistance #AutoimmuneDisease #GutHealth #PlantToxins #WheatGermAgglutinin #FattyLiver #Inflammation #DrBenBikman #KetoScience #LowCarbLife #MetabolicHealth #CRP #GlucoseControl #PPARgamma #Antinutrients #WholeGrains #AdiposeInflammation #FunctionalMedicine Timestamps (approximate): 01:21 – What Are Lectins and Where Are They Found? 03:32 – Cooking Reduces Lectins but Doesn’t Eliminate Them 05:54 – Leaky Gut, Inflammation, and Insulin Resistance 06:59 – Lectins and IBS, Crohn’s, Autoimmune Conditions 08:05 – Lectins Interact with Insulin Receptors 09:18 – Lectins Mimic and Disrupt Insulin Function 12:09 – Cardiovascular Effects: Lectins and Plaque Formation 13:20 – Lectins and Blood Vessel Inflammation 15:26 – Lectins Increase Liver Fat and Impair Insulin Signaling 16:49 – Lectins as Immune System Triggers 19:48 – Who Should Avoid Lectins? 20:47 – Pressure Cooking, Biomarkers, and Practical Advice 22:49 – Summary: Lectins and Metabolic Health Ben’s favorite yerba maté and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) Ben’s favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15) Ben’s favorite exogenous ketone: https://ketone.com/BEN30 (discount: BEN30) Other products Ben likes: https://www.amazon.com/shop/benbikmanphd